Propolis Powder is widely used in natural therapies due to its high bioactive content (e.g., total flavonoids ≥8% and polyphenols ≥20%). Its basic mechanisms of action are antimicrobial (MIC to inhibit Staphylococcus aureus is 0.1mg/mL), anti-inflammatory (inhibition of COX-2 activity up to 65%), and immunomodulatory (increase in NK cell activity by 40%). A 2023 Journal of Ethnopharmacology study revealed that daily once 300mg oral propolis powder reduced incidence of influenza by 55% (12% control group) and reduced duration of illness by 2.5 days (median 7 days →4.5 days).
In cosmetics, Propolis Powder repairs damaged tissue via collagen production stimulated (35% increase at 1% concentration) and MMP-1 enzyme inhibition (48% reduction). Clinical trials show acne patients who take the topical gel in the form of 5% propolis powder (twice daily) in 4 weeks have inflammatory papules reduce by 67% (reduced 22% with a placebo), with sebum reducing by 40%. In burn model, propolis powder with 2% concentration decreased the healing time to 14 days (21 days in control group), and the percentage of scar hyperplasia was reduced by 50%.
In relation to immune response, CAPE (phenethyl cafeate) fraction of Propolis Powder inhibited IL-6 (52%) and TNF-α (45%) release by inhibiting the NF-κB signaling pathway. A randomized trial in HIV patients (n=120) found that daily supplementation with 500mg propolis powder increased CD4+ cell count by 18% (baseline 250 cells/μL→295 cells/μL) and reduced risk of opportunistic infections by 40%.
Dental health apps validate common sense. Propolis powder gargle (concentration 10%) can shorten the healing time of oral ulcer from 7 days to 3 days (effective rate 92%), and inhibit the adhesion rate of periodontal pathogen (such as porphyromonas gingivalis) ≥70%. A study at the University of Sao Paulo in Brazil found that after 6 months of use of toothpaste containing propolis powder (2% concentration), the gum bleeding index was reduced by 55% (15% in the control group) and dental caries incidence by 30%.
Digestive and respiratory system protection. Propolis Powder Artepillin C (≥1.5%) inhibited H1N1 virus replication (IC50=2.3μM), whereas with oseltamivir inhibited it to a rise of 88% from 65%. In chronic gastritis patients (n=200) treated with 400mg/day propolis powder, Helicobacter pylori eradication was raised to 78% after 8 weeks (72% control triple therapy group), and gastric mucosal repair rate was raised by 40%.
Long-term use is confirmed by security. Toxicological assessment confirmed that Propolis Powder LD50 was > 5,000mg/kg (rats) and no difference in liver function markers (ALT/AST) after long-term use (12 months). It is authorized by the European Union EFSA as a food additive (daily maximum amount 70mg/kg body weight), and incidence of allergic reaction is merely 0.3% (8% among peanut allergy patients).
Market data is confirmed to show the growth of demand. In 2023, the global propolis powder market will be 1.2 billion US dollars, with a year-over-year growth rate of 9%, and dietary supplements occupy 45% among them. The TOP5 natural immunity products on the Amazon platform all contain propolis ingredients, with a repurchase rate of more than 50% (industry average is 25%). Brazilian company Green Propolis has raised the price of its export to 120/kg (80 for non-certified products) with organic certification (USDA), increasing its margin by 35%.
From bench to clinic, Propolis Powder is supported by multi-target, high safety and traditional wisdom to become the featured ingredient of natural therapies, serving multi-dimensional health needs such as immune enhancement, skin repair and oral care.